免疫疗法
肿瘤微环境
医学
癌变
癌症研究
转移
免疫学
表型
肿瘤细胞
免疫系统
癌症
生物
内科学
生物化学
基因
作者
Bin Shi,Meng Du,Zhiyi Chen
标识
DOI:10.1080/1744666x.2024.2438721
摘要
Introduction In recent years, immunotherapy has shown significant therapeutic potential in patients with advanced tumors. However, only a small number of individuals benefit, mainly due to the tumor microenvironment (TME), which provides conditions for the development of tumors. Macrophages in TME, known as tumor-associated macrophages (TAM), are mainly divided into M1 anti-tumor and M2 pro-tumor phenotypes, which play a regulatory role in various stages of tumorigenesis, promote tumorigenesis and metastasis, and cause immunotherapy resistance.
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