连接器
对偶(语法数字)
对称化
化学
组合化学
块(置换群论)
计算机科学
生化工程
计算生物学
有机化学
生物
工程类
程序设计语言
对映选择合成
数学
文学类
艺术
催化作用
几何学
作者
Stefan G. Koenig,Rémy Angelaud,Christopher M. Crittenden,Kenji L. Kurita,David J. Russell,Jean-François Marcoux,Thomas Matt,Francis Gosselin
标识
DOI:10.1021/acs.oprd.2c00129
摘要
The synthetic strategies for two distinct but related linker-toxins 1 and 2 were reconfigured in order to devise an efficient and unified supply chain for both compounds. This involved establishing novel chemical routes to crystalline, monomeric building blocks that could be combined in a unique way for each molecular target. This streamlined approach avoided challenging desymmetrization efforts en route to each target molecule as well as a drastically reduced need for multiple chromatographic purifications throughout the syntheses. In the final instance, the shared-building-block concept enabled access to advanced intermediates from which the optimized endgames were implemented, ultimately resulting in robust synthetic processes to both 1 and 2.
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