表观遗传学
DNA甲基化
胎盘
生物
基因组印记
基因
表型
胎儿
甲基化
基因表达调控
DNA
宫内生长受限
胎儿生长
遗传学
基因表达
怀孕
作者
Yiorgos A. Bobetsis,Silvana P. Barros,Dongming Lin,Jennifer R. Weidman,Dana C. Dolinoy,Randy L. Jirtle,Kim Boggess,James D. Beck,Steven Offenbacher
标识
DOI:10.1177/154405910708600212
摘要
Maternal oral infection, caused by bacteria such as C. rectus or P. gingivalis, has been implicated as a potential source of placental and fetal infection and inflammatory challenge, which increases the relative risk for pre-term delivery and growth restriction. Intra-uterine growth restriction has also been reported in various animal models infected with oral organisms. Analyzing placental tissues of infected growth-restricted mice, we found down-regulation of the imprinted Igf2 gene. Epigenetic modification of imprinted genes via changes in DNA methylation plays a critical role in fetal growth and development programming. Here, we assessed whether C. rectus infection mediates changes in the murine placenta Igf2 methylation patterns. We found that infection induced hypermethylation in the promoter region-P0 of the Igf2 gene. This novel finding, correlating infection with epigenetic alterations, provides a mechanism linking environmental signals to placental phenotype, with consequences for development.
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