脂肪组织
抵抗素
脂联素
心外膜脂肪组织
医学
内科学
动脉
心脏病学
腹内脂肪
代谢综合征
内分泌学
内脏脂肪
胰岛素
胰岛素抵抗
肥胖
作者
Gianluca Iacobellis,Domenico Corradi,Arya M. Sharma
出处
期刊:Nature clinical practice cardiovascular medicine
[Springer Nature]
日期:2005-10-01
卷期号:2 (10): 536-543
被引量:848
标识
DOI:10.1038/ncpcardio0319
摘要
A growing amount of evidence suggests that regional fat distribution plays an important part in the development of an unfavorable metabolic and cardiovascular risk profile. Epicardial fat is a metabolically active organ that generates various bioactive molecules, which might significantly affect cardiac function. This small, visceral fat depot is now recognized as a rich source of free fatty acids and a number of bioactive molecules, such as adiponectin, resistin and inflammatory cytokines, which could affect the coronary artery response. The observed increases in concentrations of inflammatory factors in patients who have undergone coronary artery bypass grafting remain to be confirmed in healthy individuals. Furthermore, epicardial adipose mass might reflect intra-abdominal visceral fat. Therefore, we propose that echocardiographic assessment of this tissue could serve as a reliable marker of visceral adiposity. Epicardial adipose tissue is also clinically related to left ventricular mass and other features of the metabolic syndrome, such as concentrations of LDL cholesterol, fasting insulin and adiponectin, and arterial blood pressure. Echocardiographic assessment of epicardial fat could be a simple and practical tool for cardiovascular risk stratification in clinical practice and research. In this paper, we briefly review the rapidly emerging evidence pointing to a specific role of epicardial adipose tissue both as a cardiac risk marker and as a potentially active player in the development of cardiac pathology.
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