医学
细胞因子
免疫疗法
肿瘤微环境
癌症
转移
癌症研究
免疫学
炎症
癌细胞
免疫系统
癌症免疫疗法
免疫
功能(生物学)
生物
发病机制
内科学
细胞生物学
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2004-01-01
卷期号:4 (1): 11-22
被引量:1439
摘要
The mixture of cytokines that is produced in the tumour microenvironment has an important role in cancer pathogenesis. Cytokines that are released in response to infection, inflammation and immunity can function to inhibit tumour development and progression. Alternatively, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis and facilitate invasion and metastasis. A more detailed understanding of cytokine–tumour-cell interactions provides new opportunities for improving cancer immunotherapy.
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