Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression

CancerVolume 66, Issue 1 p. 162-166 Immunology and PathologyFree Access Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression Graham R. Standen PhD, MRCP, MRCPath, Corresponding Author Graham R. Standen PhD, MRCP, MRCPath Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomDepartment of Haematology, University of Wales College of Medicine, Heath Park, Cardiff. CF4 4XN, UK===Search for more papers by this authorBharat Jasani PhD, MRCPath, Bharat Jasani PhD, MRCPath Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this authorMichael Wagstaff PhD, Michael Wagstaff PhD Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this authorCharles A. J. Wardrop FRCP, FRCPath, Charles A. J. Wardrop FRCP, FRCPath Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this author Graham R. Standen PhD, MRCP, MRCPath, Corresponding Author Graham R. Standen PhD, MRCP, MRCPath Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomDepartment of Haematology, University of Wales College of Medicine, Heath Park, Cardiff. CF4 4XN, UK===Search for more papers by this authorBharat Jasani PhD, MRCPath, Bharat Jasani PhD, MRCPath Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this authorMichael Wagstaff PhD, Michael Wagstaff PhD Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this authorCharles A. J. Wardrop FRCP, FRCPath, Charles A. J. Wardrop FRCP, FRCPath Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United KingdomSearch for more papers by this author First published: 1 July 1990 https://doi.org/10.1002/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-ZCitations: 40AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed. References 1 You W Weisbrot IM. Chronic neutrophilic leukemia: Report of two cases and review of the literature. Am J Clin Pathol 1979; 72: 233– 242. 2 Bareford D Jacobs B. Chronic neutrophilic leukemia. Am J Clin Pathol 1980; 73: 837. 3 Dotten DA Pruzanski W, Wong D. Functional characterization of the cells in chronic neutrophilic leukemia. Am J Hematol 1982; 12: 157– 165. 4 Tanzer J Harel P, Boiron M, Bernard J. Cytochemical and cytogenetic findings in a case of chronic neutrophilic leukaemia of mature cell type. Lancet 1964; 1: 387– 388. 5 Donato CD Croci G, Lazzari S, et al. Chronic neutrophilic leukemia: Description of a new case with karyotypic abnormalities. Am J Clin Pathol 1986; 85: 369– 371. 6 Tursz T Flandrin G, Brouet JC, Seligmann M. Coexistence d'un myelome et d'une leucémie granuleuse en l'absence de tout traitment: Etude de quatre observations. Nouv Rev Fr Hematol 1974; 14: 693– 704. 7 Carcassonne Y Gastaut JA, Sebahoun G, Gratecos N. Découverte simultanée chez un měme malade d'un myélome, d'une leukémie granuleuse (à polynucléaires neutrophiles) et d'une maladie de Paget. Nouv Rev Fr Hematol 1977; 18: 240– 244. 8 Vorobiof DA Benjamin J, Kaplan H, Dvilansky A. Chronic granulocytic leukaemia, neutrophilic type with paraproteinaemia (IgA type k). Acta Haematol 1978; 60: 316– 320. 9 Naparstek Y Zlotnick A, Polliack A. Coexistent chronic myeloid leukemia and IgA monoclonal gammopathy: Report of a case and review of the literature. Am J Med Sci 1980; 279: 111– 115. 10 Franchi F Seminara P, Giunchi G. Chronic neutrophilic leukaemia and myeloma: Report on long survival. Tumori 1984; 70: 105– 107. 11 Watanabe A Yoshida Y, Yamamoto H, Kimura S, Nagashima H, Kitajima K, A case of chronic neutrophilic leukaemia with paraproteinaemia (IgG type λ and IgA type k). Jpn J Med 1984; 23: 39– 44. 12 Lewis MJ, Oelbaum MH, Coleman M, Allen S. An association between chronic neutrophilic leukaemia and multiple myeloma with a study of cobalamin-binding proteins. Br J Haematol 1986; 63: 173– 180. 13 Shtivelman E Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 1985; 315: 550– 554. 14 Zoumbos NC Chrysanthopoulos C, Starakis J, Kapatais-Zoumbos K. k Light chain myeloma developing in a patient with chronic neutrophilic leukaemia. Br J Haematol 1987; 65: 504– 505. 15 Shepherd PC Ganesan TS, Galton DAG. Haematological classification of the chronic myeloid leukaemias. Clin Haematol 1987; 1: 887– 906. 16 Kantarjian HM Shtalrid M, Kurzrock R, et al. Significance and correlations of molecular analysis results in patients with Philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia. Am J Med 1988; 85: 639– 644. 17 Lorente JA Pena JM, Ferro T, et al. A case of chronic neutrophilic leukaemia with original chromosomal abnormalities. Eur J Haematol 1988; 41: 285– 288. 18 Potter M. Plasmacytomas in mice. Semin Oncol 1986; 13: 275– 281. 19 Cohen HJ Bernstein RJ, Grufferman S. Role of immune stimulation in the etiology of multiple myeloma: A case control study. Am J Hematol 1987; 24: 119– 126. 20 Kasimis BS Yen-Lin R, Neiman RS. Multiple myeloma associated with myelofibrosis. Oncology 1981; 38: 369– 372. 21 Ghosh P. Essential thrombocythaemia and Bence Jones myeloma. Br Med J 1984; 289: 228. 22 Maeda K Abraham J. Polycythemia associated with myeloma. Am J Clin Pathol 1984; 82: 501– 505. 23 Epstein J. Barlogie B Katzmann J, Alexanian R. Phenotypic heterogeneity in aneuploid multiple myeloma indicates pre-B cell involvement. Blood 1988; 71: 861– 865. 24 Gould J Goodacre A, Pathak S, Alexanian R, Barlogie B, Karyo-type correlations with clinical features in multiple myeloma (Abstr). Blood 1986; (Suppl) 68: 209. 25 Lee MS Selvanayagam P, Alexanian R, Stass S, Barlogie B, Rearrangements (REARR) of T-cell receptor (TcR) gamma chain gene in multiple myeloma (Abstr). Proc Am Assoc Cancer Res 1987; 28: 178. 26 Grogan TM Durie BGM, Spier CM, Richter L, Vela E, Myelomonocytic antigen positive multiple myeloma. Blood 1989; 73: 763– 769. 27 Vogelstein B Fearon ER, Hamilton SR, Feinberg AP. Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science 1985; 227: 642– 645. 28 Nakanishi T Sobue I, Toyokura Y, et al. The Crow-Fukase syndrome: a study of 102 cases in Japan. Neurology 1984; 34: 712– 720. 29 Radaszkiewicz T Hansmann ML, Lennert K. Monoclonality and polyclonality of plasma cells in Castleman's disease of the plasma cell variant. Histopathology 1989; 14: 11– 24. 30 Swerdlow SH Murray LJ, Habeshaw JA. Are kappa and lambda light chain-bearing B cells functionally distinct? Immunology Today 1985; 6: 200. 31 Chilosi M Pizzolo G, Caligaris-Cappio F, et al. Immunohisto-chemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukaemia. Cancer 1985; 56: 328– 332. Citing Literature Volume66, Issue11 July 1990Pages 162-166 ReferencesRelatedInformation