Synthesis of L‐[35S]homocysteine thiolactone hydrochloride

Abstract L‐[ 35 S]Homocysteine thiolactone has been synthesized by demethylation of L‐[ 35 S]Methionine with sodium in liquid ammonia and subsequent lactonisation in acid solution. The radiochemical yield of the carrier added synthesis was in the range of 45 to 50 % with a radiochemical purity higher than 96 %.