磷酸化
生物
脱磷
基因
磷酸化级联
蛋白质磷酸化
信号转导
基因表达调控
细胞生物学
转录因子Sp1
基因表达
遗传学
发起人
蛋白激酶A
磷酸酶
作者
Shijian Chu,Thomas J. Ferro
出处
期刊:Gene
[Elsevier BV]
日期:2005-03-01
卷期号:348: 1-11
被引量:225
标识
DOI:10.1016/j.gene.2005.01.013
摘要
As the prototype of a family of transcription factors, Sp1 has been extensively studied and widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was reported more than a decade ago. Since then, an increasing number of Sp1 phosphorylation events have been characterized. Recent data demonstrate an important role for the phosphorylation state of Sp1 in the regulation of multiple genes. In this article, we review published literature in four specific areas relating to the phosphorylation of Sp1: (1) signal transduction pathways for Sp1 phosphorylation, (2) mechanisms of Sp1 dephosphorylation, (3) the functional implications of Sp1 phosphorylation, and (4) Sp1 phosphorylation in the lung.
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