花生四烯酸
环氧合酶
精神分裂症(面向对象编程)
二十烷酸
医学
环氧二十碳三烯酸
塞来昔布
病理生理学
神经科学
药理学
内科学
心理学
生物
精神科
酶
生物化学
作者
Kunio Yui,George Imataka,Hiroyuki Nakamura,Naoki Ohara,Yukiko Naito
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2015-11-26
卷期号:13 (6): 776-785
被引量:80
标识
DOI:10.2174/1570159x13666151102103305
摘要
Arachidonic acid (AA)-derived lipid mediators are called eicosanoids. Eicosanoids have emerged as key regulators of a wide variety of physiological responses and pathological processes, and control important cellular processes. AA can be converted into biologically active compounds by metabolism by cyclooxygenases (COX). Beneficial effect of COX-2 inhibitor celecoxib add-on therapy has been reported in early stage of schizophrenia. Moreover, add-on treatment of celecoxib attenuated refractory depression and bipolar depression. Further, the COX/prostaglandin E pathway play an important role in synaptic plasticity and may be included in pathophysiology in autism spectrum disorders (ASD). In this regard, plasma transferrin, which is an iron mediator related to eicosanoid signaling, may be related to social impairment of ASD. COX-2 is typically induced by inflammatory stimuli in the majority of tissues, and the only isoform responsible for propagating the inflammatory response. Thus, COX-2 inhibitors considered as the best target for Alzheimer's disease.
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