The limbic forebrain plays an important role in regulation of emotion and stress, water- and electrolyte-balance. All these activities are accompanied with changes of cardiovascular activities, and many pressor- and depressor-areas in the limbic forebrain are involved in regulating these activities. Recently, along with the studies on the mechanisms underlying cardiovascular effects of various areas in brainstem, studies on mechanisms underlying effects of pressor- and depressor-areas in forebrain have also made great progress. This review briefly introduces the relationships among cardiovascular centers in limbic forebrain, and the functional connections between these centers and brainstem areas, including the transmitters and receptors involved.