医学
唑吡坦
麻醉
单光子发射计算机断层摄影术
药品
唤醒
偏头痛
药理学
神经科学
内科学
心理学
失眠症
作者
Ralf Clauss,W M Güldenpfennig,H.W. Nel,Mike Sathekge,R R Venkannagari
出处
期刊:PubMed
日期:2000-01-01
卷期号:90 (1): 68-72
被引量:79
摘要
A young semi-comatose male patient was investigated using 99mTc hexamethyl-propylene amine oxime (99mTc HMPAO) brain single photon emission computed tomography (SPECT) before and after administration of the gamma-aminobutyric acid (GABA) agonist zolpidem. It was observed that 15 minutes after application of the drug the patient awoke from his semi-comatose condition and remained awake for the next 3-4 hours. When drug action subsided he returned to his semi-comatose state. Brain SPECT before drug application showed large hypo-active areas in certain parts of the brain. Brain SPECT after drug application showed a generalised cortical activation relative to the cerebellum and a marked and amplified activation of the areas that were hypo-active before drug application.
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