A combined oral contraceptive containing 3-mg drospirenone/ 20-microg ethinyl estradiol in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment.

医学 安慰剂 屈螺酮 痤疮 养生 药丸 内科学 炔雌醇 人口 随机对照试验 妇科 药理学 皮肤病科 替代医学 环境卫生 病理 研究方法
作者
Anne W. Lucky,William Koltun,Diane Thiboutot,Minoo Niknian,Carole Sampson-Landers,Paul Körner,Joachim Marr
出处
期刊:PubMed 卷期号:82 (2): 143-50 被引量:31
链接
标识
摘要

This study compared the efficacy of a low-dose combined oral contraceptive (COC) containing 3-mg drospirenone and 20-microg ethinyl estradiol (3-mg DRSP/20-microg EE) administered in a 24-day active pill/4-day inert pill (24/4) regimen and placebo in women with moderate acne vulgaris during 6 treatment cycles. A total of 534 participants were randomized and dispensed study medication (n = 266 [3-mg DRSP/20-microg EE 24/4 regimen COC group]; n = 268 [placebo group]). Women of reproductive age were eligible for inclusion in the study. Treatment with the 3-mg DRSP/20-microg EE 24/4 regimen COC was associated with a greater reduction from baseline to end point in individual lesion counts (papules, pustules, open and closed comedones) compared with placebo. The mean nodule count remained essentially constant throughout the study and was low in both treatment groups. There was a significantly higher probability that a participant had an improved assessment on the investigator's overall improvement rating scale (odds ratio [OR], 4.02; 95% CI [confidence interval], 2.29-7.31; P < .0001) and participant's overall self-assessment rating scale (OR, 2.82; 95% CI, 1.60-5.13; P = .0005) in the 3-mg DRSP/20-microg EE 24/4 regimen COC group than in the placebo group. The COC 3-mg DRSP/20-microg EE 24/4 regimen is a suitable option for women with moderate acne vulgaris who require contraception.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
up完成签到,获得积分10
刚刚
SciGPT应助qian采纳,获得10
1秒前
1秒前
传奇3应助科研通管家采纳,获得30
2秒前
自觉香旋应助科研通管家采纳,获得10
2秒前
小蘑菇应助科研通管家采纳,获得10
2秒前
新火应助科研通管家采纳,获得20
2秒前
上官若男应助科研通管家采纳,获得10
2秒前
酷波er应助科研通管家采纳,获得10
2秒前
天天快乐应助科研通管家采纳,获得10
2秒前
2秒前
2秒前
4秒前
Alephas发布了新的文献求助10
4秒前
我是老大应助sys采纳,获得10
4秒前
6秒前
7秒前
初心完成签到,获得积分10
8秒前
CodeCraft应助hello采纳,获得10
11秒前
感性的安露应助研友_Z7XY28采纳,获得20
11秒前
zzzzzx发布了新的文献求助10
12秒前
安然发布了新的文献求助20
13秒前
stuffmatter应助victory_liu采纳,获得10
15秒前
丘比特应助谷蓝采纳,获得10
16秒前
柯镇恶完成签到,获得积分10
19秒前
20秒前
田様应助眼睛大水蓝采纳,获得10
20秒前
20秒前
wangshuhong发布了新的文献求助10
23秒前
Alephas完成签到,获得积分10
25秒前
天天快乐应助zzzzzx采纳,获得10
25秒前
金东华完成签到,获得积分10
26秒前
研友_Z7XY28完成签到,获得积分10
27秒前
zoujianqiao完成签到 ,获得积分10
27秒前
俭朴蜜蜂完成签到 ,获得积分10
28秒前
28秒前
研友_Z7XY28发布了新的文献求助20
30秒前
32秒前
dodo应助安然采纳,获得20
33秒前
Song发布了新的文献求助10
34秒前
高分求助中
LNG地下式貯槽指針(JGA指-107-19)(Recommended practice for LNG inground storage) 1000
Second Language Writing (2nd Edition) by Ken Hyland, 2019 1000
rhetoric, logic and argumentation: a guide to student writers 1000
QMS18Ed2 | process management. 2nd ed 1000
Eric Dunning and the Sociology of Sport 850
Operative Techniques in Pediatric Orthopaedic Surgery 510
A High Efficiency Grating Coupler Based on Hybrid Si-Lithium Niobate on Insulator Platform 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2921442
求助须知:如何正确求助?哪些是违规求助? 2564267
关于积分的说明 6935774
捐赠科研通 2221720
什么是DOI,文献DOI怎么找? 1180966
版权声明 588787
科研通“疑难数据库(出版商)”最低求助积分说明 577791