The Emergence of the Potential Therapeutic Targets: Ultrasound-Based Radiomics in the Prediction of Human Epidermal Growth Factor Receptor 2-Low Breast Cancer

无线电技术 人表皮生长因子受体2 乳腺癌 表皮生长因子受体 肿瘤科 医学 超声波 癌症研究 表皮生长因子 内科学 癌症 受体 放射科
作者
Yu Du,Fang Li,Manqi Zhang,Jiazhen Pan,Ting‐Ting Wu,Yi Zheng,Jing Chen,Minghua Yao,Yi Kuang,Rong Wu,Xuehong Diao
出处
期刊:Academic Radiology [Elsevier BV]
卷期号:31 (7): 2674-2683 被引量:6
标识
DOI:10.1016/j.acra.2024.01.023
摘要

Rationale and Objectives

To evaluate whether ultrasound-based radiomics features can effectively predict HER2-low expression in patients with breast cancer (BC).

Material and Methods

Between January 2021 and June 2023, patients who received US scans with pathologically confirmed BC in this multicenter study were included. In total, 383 patients from institution 1 were comprised of training set, 233 patients from institution 2 were comprised of validation set and 149 patients from institution 3 were comprised of external validation set. Radiomics features were derived from conventional ultrasound (US) images. The minimum redundancy and maximum relevancy and the least absolute shrinkage and selector operation algorithm were used to generate an US-based radiomics score (RS). Multivariable logistic regression analysis was used to select variables associated with HER2 expressions. The diagnostic performance of the RS was evaluated through the area under the receiver operating characteristic curve (AUC).

Results

In the training set, the RS yield an AUC of 0.81 (95%CI: 0.76–0.84) for differentiation HER2-zero from HER2-low and -positive cases, and performed well in validation set (AUC 0.84, 95%CI: 0.78–0.88) and external validation set (AUC 0.82, 95%CI: 0.73–0.90). In the subgroups analysis, the RS showed good performance in distinguishing HER2-zero from HER2 1 + , HER2 2 + and HER2-low tumors (AUC range, 0.79–0.87).

Conclusion

The RS based on conventional US is proven effective for predicting HER2-low expression in BC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tqmx完成签到,获得积分10
1秒前
joy发布了新的文献求助10
1秒前
Brad_AN完成签到,获得积分10
1秒前
1秒前
1秒前
1秒前
MrX完成签到,获得积分10
3秒前
zhaoyaoshi完成签到 ,获得积分10
3秒前
Avery完成签到,获得积分10
3秒前
谦让文昊完成签到,获得积分10
3秒前
典雅碧空发布了新的文献求助10
3秒前
REN发布了新的文献求助10
4秒前
谨言完成签到 ,获得积分10
4秒前
Akim应助Ma采纳,获得10
5秒前
zdd发布了新的文献求助10
5秒前
西红柿呀完成签到,获得积分10
5秒前
6秒前
6秒前
靓丽行天完成签到,获得积分10
6秒前
崔尔蓉完成签到,获得积分10
7秒前
玉玉完成签到,获得积分10
7秒前
不羁完成签到 ,获得积分10
7秒前
7秒前
LM完成签到,获得积分10
8秒前
En完成签到,获得积分0
8秒前
爱情哈尔完成签到,获得积分10
8秒前
8秒前
lalkiii完成签到,获得积分10
8秒前
unflycn完成签到,获得积分10
8秒前
8秒前
wyn完成签到,获得积分10
9秒前
9秒前
hhhhhhhhhh完成签到 ,获得积分10
9秒前
lm完成签到 ,获得积分10
9秒前
fuyuhaoy完成签到,获得积分10
9秒前
wanci应助majf采纳,获得10
9秒前
冲天小猪完成签到,获得积分10
10秒前
10秒前
章鱼哥完成签到,获得积分10
10秒前
11秒前
高分求助中
Nickel, Cobalt and Palladium Catalysed Infarction with Ventricular following rich structural diversity 1000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968608
求助须知:如何正确求助?哪些是违规求助? 3513486
关于积分的说明 11168243
捐赠科研通 3248926
什么是DOI,文献DOI怎么找? 1794540
邀请新用户注册赠送积分活动 875188
科研通“疑难数据库(出版商)”最低求助积分说明 804676