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Non-negligible vector effect of micro(nano)plastics on tris(1,3-dichloro-2-propyl) phosphate in zebrafish quantified by toxicokinetic model

生物累积 化学 毒物动力学 环境化学 毒性 有机化学
作者
Ning Gao,Lanpeng Yang,Xueqiang Lu,Lin Zhu,Jianfeng Feng
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:463: 132928-132928
标识
DOI:10.1016/j.jhazmat.2023.132928
摘要

Micro(nano)plastics (MNPs) inevitably interact with coexisting contaminants and can act as vectors to affect their fate in organisms. However, the quantitative contribution of MNPs in the in vivo bioaccumulation and distribution of their coexisting contaminants remains unclear. Here, by selecting tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) as the typical coexisting contaminant, we quantified the contribution of MNPs to bioaccumulation and distribution of TDCIPP with toxicokinetic models. Results indicated that MNPs differentially facilitated TDCIPP bioaccumulation and distribution, and NPs slowed down TDCIPP depuration more significantly than MPs. Model analysis further revealed increasing contributions of MNPs to whole-fish TDCIPP bioaccumulation over time, with NPs (33-42%) contributing more than MPs (12-32%) at 48 h exposure. NPs contributed more than MPs to TDCIPP distribution in the liver (13-19% for MPs; 36-52% for NPs) and carcass (24-45% for MPs; 57-71% for NPs). The size-dependent vector effect might be attributed to the fact that MNPs promote contaminant transfer by damaging biofilm structure and increasing tissue membrane permeability, with NPs exerting stronger effects. This work demonstrated the effectiveness of using modeling tools to understand the relative importance of MNPs as contaminant vectors in the TK process and highlighted the higher contaminant transfer potential of NPs under combined exposure scenarios. Micro(nano)plastics (MNPs) inevitably interact with coexisting contaminants in aquatic environments, yet it is unclear how MNPs act as vectors to influence the fate of coexisting contaminants in aquatic organisms. We quantified the size-dependent vector effect of MNPs on TDCIPP bioaccumulation and distribution using toxicokinetic models. NPs exhibited higher contaminant transfer potential compared to MPs. This study contributes time-dimensional insights to better understand the role of MNPs in the toxicokinetic process of contaminants and the associated environmental risks under more realistic exposure scenarios. Our findings provide a reliable strategy and theoretical basis for the risk management of MNPs and coexisting contaminants.
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