骨桥蛋白
纤维化
细胞外基质
生物标志物
癌症研究
病理
医学
生物
免疫学
细胞生物学
遗传学
作者
Ziyi Tang,Zijing Xia,Xiangpeng Wang,Yi Liu
标识
DOI:10.1016/j.cytogfr.2023.08.007
摘要
Fibrosis is a pathological condition characterized by the excessive deposition of extracellular matrix components in tissues and organs, leading to progressive architectural remodelling and contributing to the development of various diseases. Osteopontin (OPN), a highly phosphorylated glycoprotein, has been increasingly recognized for its involvement in the progression of tissue fibrosis. This review provides a comprehensive overview of the genetic and protein structure of OPN and focuses on our current understanding of the role of OPN in the development of fibrosis in the lungs and other tissues. Additionally, special attention is given to the potential of OPN as a biomarker and a novel therapeutic target in the treatment of fibrosis.
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