Imaing the brain microstructures in patients of severe enlarged perivasclar spaces in the basal ganglia region using diffusion kurtosis imaging

This study used DKI to investigate possible microstructural alterations of brain tissues associated with plenty of EPVS in the basal ganglia (BG) in patients of SVD. Our preliminary results revealed that patients with EPVS in the BG showed significant reductions in kurtosis parameters from DKI and elevated diffusion parameters derived from DKI in bilateral putamen. We also found abnormal diffusion parameters in mainly bilateral BG, limbic system, temporal lobe,and other scatter brain regions. Our data suggests patients with plenty of EPVS in the BG might undergo microstructure impairments in the regions above, especially bilateral insular and BG.