紧身衣
共价有机骨架
共价键
材料科学
纳米技术
纳米材料
连接器
单体
高分子
纳米颗粒
组合化学
荧光
化学工程
聚合物
化学
有机化学
计算机科学
复合材料
工程类
物理
操作系统
量子力学
生物化学
作者
Fátima Suárez‐Blas,Marcos Martínez‐Fernández,Alejandro Prieto‐Castañeda,Alba García‐Fernández,José I. Martínez,Mar Ramos,María J. Ortiz,Ramón Martínez‐Máñez,José L. Segura
标识
DOI:10.1016/j.dyepig.2023.111561
摘要
Covalent organic Frameworks (COFs) are a class of crystalline macromolecular materials build-up by monomers with specific symmetries or functionalities. There are important limitations in the synthesis of highly ordered COFs, such as the shape and packing of the building blocks. Thus, the presence of fluorine atoms that lie perpendicular to the bisecting plane of BODIPY derivatives together with the presence of four bulky methyl groups could hinder the crystallization process in COF synthesis. For that reason, BODIPY-based COFs are rarely incorporated to COF networks. In this work, following the mixed linker strategy, a pre-synthetic method to dope COF structures with BODIPY units was developed. The materials have been processed into fluorescent Covalent Organic Nanosheets (CONs) with defined particle-size distributions around 100 nm, suitable for cellular biomedical applications. The viability of the CONs was evaluated using Sk-Mel-103 cells, demonstrating the internalization showing 100% cell viability. We envisage that this work could accelerate the discovery of new COF-based materials for biomedical sciences.
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