免疫疗法
前列腺癌
免疫系统
癌症研究
基因签名
生物
前列腺
免疫检查点
基因
医学
肿瘤科
癌症
免疫学
基因表达
内科学
遗传学
作者
Xianyanling Yi,Jin Li,Xiaonan Zheng,Hang Xu,Dazhou Liao,Tianyi Zhang,Qiang Wei,Hong Li,Jiajie Peng,Jianzhong Ai
标识
DOI:10.1016/j.omtn.2023.07.010
摘要
PANoptosis pathway gene sets encompassing pyroptosis, apoptosis, and necroptosis were identified from the MSigDB database. We analyzed the perturbations and crosstalk in the PANoptosis pathway in prostate adenocarcinoma (PRAD), including gene mutation, transcription, methylation, and clinical features. By constructing a PANoptosis signature, we accurately predicted the prognosis and immunotherapeutic response of PRAD patients. We further explored the molecular features and immunological roles of the signature, dividing patients into high- and low-score groups. Notably, the high-score group correlated with better survival outcomes and immunotherapeutic responses, as well as a higher mutation frequency and enrichment score in the PANoptosis and HALLMARK pathways. The PANoptosis signature also enhanced overall antitumor immunity, promoted immune cell infiltration, upregulated immune checkpoint regulators, and revealed the cold tumor characteristics of PRAD. We also identified potential drug targets based on the PANoptosis signature. These findings lead the way in identifying novel prognostic markers and therapeutic targets for patients with PRAD.
科研通智能强力驱动
Strongly Powered by AbleSci AI