恶病质
GDF15型
减肥
癌症恶病质
医学
癌症
热量理论
内分泌学
内科学
肥胖
作者
Ja Young Kim-Muller,LouJin Song,Brianna LaCarubba Paulhus,Evanthia Pashos,Xiangping Li,Anthony Rinaldi,Stephanie Joaquim,John C. Stansfield,Jiangwei Zhang,Andrew W. Robertson,Jincheng Pang,Alan Opsahl,Magalie Boucher,Danna M. Breen,Katherine Hales,Abdul Q. Sheikh,Zhidan Wu,Bei B. Zhang
出处
期刊:Cell Reports
[Elsevier]
日期:2023-01-01
卷期号:42 (1): 111947-111947
被引量:27
标识
DOI:10.1016/j.celrep.2022.111947
摘要
Cancer cachexia is a disorder characterized by involuntary weight loss and impaired physical performance. Decline in physical performance of patients with cachexia is associated with poor quality of life, and currently there are no effective pharmacological interventions that restore physical performance. Here we examine the effect of GDF15 neutralization in a mouse model of cancer-induced cachexia (TOV21G) that manifests weight loss and muscle function impairments. With comprehensive assessments, our results demonstrate that cachectic mice treated with the anti-GDF15 antibody mAB2 exhibit body weight gain with near-complete restoration of muscle mass and markedly improved muscle function and physical performance. Mechanistically, the improvements induced by GDF15 neutralization are primarily attributed to increased caloric intake, while altered gene expression in cachectic muscles is restored in caloric-intake-dependent and -independent manners. The findings indicate potential of GDF15 neutralization as an effective therapy to enhance physical performance of patients with cachexia.
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