量子点
共轭体系
碲化镉光电
材料科学
细胞凋亡
体内
圆二色性
癌细胞
纳米技术
吸收(声学)
手性(物理)
配体(生物化学)
生物物理学
癌症
化学
立体化学
受体
生物化学
生物
聚合物
物理
手征对称性
复合材料
遗传学
生物技术
Nambu–Jona Lasinio模型
量子力学
夸克
作者
Guangmin Li,Xihao Zhang,Xuening Fei,Jiafeng Li,Hongfei Liu,Wei Liu,Yang Yang,Bingjing Li,Mingrui Liu,Gaoling Yang,Ti Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-08-15
卷期号:16 (8): 12991-13001
被引量:13
标识
DOI:10.1021/acsnano.2c05517
摘要
Inducing apoptosis in cancer cells is considered a potential therapeutic mechanism underlying cancers. Here, chiral folic acid (FA) conjugated Cys-CdTe/CdS quantum dots (QDs) conjugated with a cancer-targeting ligand were fabricated to induce apoptosis in vivo. Ligand-induced chirality mechanism for FA-Cys-CdTe/CdS QDs was discussed, which is verified by density functional theory (DFT) simulation. Interestingly, we found that the circular dichroism (CD) signals of chiral QDs can effectively distinguish breast cancer cells from normal cells, where a sharp decrease in CD signal and absorption intensity can be seen. Notably, chiral FA-Cys-CdTe/CdS QDs showed significant apoptosis-inducing ability after the release of mitochondrial apoptotic factors. Furthermore, in vivo experiments showed that chiral FA-Cys-CdTe/CdS QDs provide an efficient cancer ablation through the apoptosis process with negligible toxicity, demonstrating their great potential utility in targeted anticancer agent for future clinic application.
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