Recovery-model: A model for CAR T-cell-related thrombocytopenia in relapsed/refractory multiple myeloma

血小板 多发性骨髓瘤 细胞因子释放综合征 耐火材料(行星科学) 胃肠病学 医学 内科学 免疫学 嵌合抗原受体 免疫疗法 癌症 天体生物学 物理
作者
Zhe Li,Yimei Que,Di Wang,Jie Lü,Chunhui Li,Menglei Xu,Zhiqiong Wang,Qiuxia Yu,Xiaolu Long,Ning An,Yi Xiao,Chunrui Li
出处
期刊:Thrombosis Research [Elsevier]
卷期号:227: 62-70 被引量:2
标识
DOI:10.1016/j.thromres.2023.05.016
摘要

Background Patients with multiple myeloma (MM) treated with anti-B cell maturation antigen (BCMA) and chimeric antigen receptor (CAR) T-cell therapy tend to show delayed platelet recovery. Patients and methods This single-center retrospective observational study included a cohort of patients with MM treated with anti-BCMA CAR-T cells in ChiCTR-OPC-16009113, ChiCTR1800018137, and ChiCTR1900021153. Results Fifty-eight patients with MM treated with anti-BCMA CAR-T cells were included. Delayed platelet recovery (platelet count not recovering to 50 × 109/L within 28 days) was observed in 36 % of patients. Regression analysis identified several factors that influenced platelet recovery, and accordingly, a Recovery-Model was developed. A high Recovery-Model score indicates a greater risk of delayed platelet recovery after CAR-T cell infusion and reflects the risk of hematologic toxicity. The model's predictive biomarkers included baseline platelet count, baseline hemoglobin level, logarithm of baseline Ferritin level, and cytokine release syndrome grade. Finally, survival analysis showed a significant relationship between overall survival, delayed platelet recovery (p = 0.0457), and a high Recovery-Model score (p = 0.0011). Conclusions Inflammation-related factors and bone marrow reserves are associated with delayed platelet recovery. Therefore, we developed a model to predict the risk of delayed platelet recovery and hematological toxicity in relapsed/refractory patients with MM after anti-BCMA CAR-T cell treatment.
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