髓鞘少突胶质细胞糖蛋白
视神经炎
医学
多发性硬化
免疫学
脑脊髓炎
抗体
急性播散性脑脊髓炎
髓鞘
免疫系统
少突胶质细胞
病理
神经科学
中枢神经系统
实验性自身免疫性脑脊髓炎
生物
内科学
出处
期刊:PubMed
日期:2023-06-01
卷期号:75 (6): 711-719
标识
DOI:10.11477/mf.1416202406
摘要
The antibody against myelin oligodendrocyte glycoprotein (MOG) has been identified for its association with several clinical phenotypes including acute or multiphasic disseminated encephalomyelitis, optic neuritis, NMOSD, and brainstem or cerebral cortical encephalomyelitis, and now generally called MOG associated disorders (MOGAD). Recent brain-biopsied MOG-antibody-positive case reports have suggested the dominance of humoral immunity, and the humoral and cellular immune responses against MOG is elucidated to develop perivenous inflammatory demyelination. In this review, we will focus on the clinical, pathological, and treatment strategies for MOG-antibody-related diseases.
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