The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis

非酒精性脂肪肝 医学 内科学 肠道微生物群 荟萃分析 脂肪肝 基因组 非酒精性脂肪性肝炎 微生物群 计算生物学 生物信息学 疾病 基因 生物 遗传学
作者
Yijia Song,Sutong Liu,Lihui Zhang,Wenxia Zhao,Yuanmei Qin,Minghao Liu
出处
期刊:Frontiers in Nutrition [Frontiers Media]
卷期号:11
标识
DOI:10.3389/fnut.2024.1470185
摘要

The incidence of NAFLD is increasing. Preclinical evidences indicate that modulation of the gut microbiome could be a promising target in nonalcoholic fatty liver disease. A systematic review and network meta-analysis was conducted to compare the effect of probiotics, synbiotics, prebiotics, fecal microbiota transplant, and antibiotics on the liver-enzyme, metabolic effects and liver-specific in patients with NAFLD. The randomized controlled trails (RCTs), limited to English language were searched from database such as Pubmed, Embase, Web of science and Cochrane Library from inception to November 2024. Review Manager 5.3 was used to to draw a Cochrane bias risk. Inconsistency test and publication-bias were assessed by Stata 14.0. Random effect model was used to assemble direct and indirect evidences. The effects of the intervention were presented as mean differences with 95% confidence interval. A total of 1921 patients from 37 RCTs were eventually included in our study. 23 RCTs evaluated probiotics, 10 RCTs evaluated synbiotics, 4 RCTs evaluated prebiotics, 3 RCTs evaluated FMT and one RCT evaluated antibiotics. Probiotics and synbiotics were associated with a significantly reduction in alanine aminotransferase [ALT, (MD: -5.09; 95%CI: -9.79, -0.39), (MD: -7.38, 95CI%: -11.94, -2.82)] and liver stiffness measurement by elastograph [LSM, (MD: -0.37;95%CI: -0.49, -0.25), (MD: -1.00;95%CI: -1.59, -0.41)]. In addition to, synbiotics was superior to probiotics in reducing LSM. Synbiotics was associated with a significant reduction of Controlled Attenuation Parameter [CAP, (MD: -39.34; 95%CI: -74.73, -3.95)]. Both probiotics and synbiotics were associated with a significant reduction of aspartate transaminase [AST, (MD: -7.81; 95%CI: -15.49, -0.12), (MD: -13.32; 95%CI: -23, -3.64)]. Probiotics and Allogenic FMT was associated with a significant reduction of Homeostatic Model Assessment for Insulin Resistance [HOMA-IR, (MD: -0.7, 95%CI: -1.26, -0.15), (MD: -1.8, 95%CI: -3.53, - 0.07)]. Probiotics was associated with a significant reduction of body mass index [BMI, MD: -1.84, 95%CI: -3.35, -0.33]. The supplement of synbiotics and probiotics maybe a promising way to improve liver-enzyme, LSM, and steatosis in patients with NAFLD. More randomized controlled trials are needed to determine the efficacy of FMT and antibiotics on NAFLD. And the incidence of adverse events of MTTs should be further explored. https://www.crd.york.ac.uk/prospero/, CRD42023450093.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
41应助momo采纳,获得10
刚刚
长情琦完成签到,获得积分10
1秒前
1秒前
研友_yLpYkn完成签到,获得积分10
1秒前
Mr兔仙森发布了新的文献求助10
1秒前
2秒前
5秒前
xueyu发布了新的文献求助10
5秒前
5秒前
文献完成签到 ,获得积分10
6秒前
levicho发布了新的文献求助10
7秒前
KK发布了新的文献求助10
8秒前
9秒前
Norl_Corxilea发布了新的文献求助10
10秒前
CodeCraft应助愉快的宛儿采纳,获得10
11秒前
一方通行发布了新的文献求助10
11秒前
levicho完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
14秒前
15秒前
Norl_Corxilea完成签到,获得积分10
16秒前
19秒前
我是老大应助Culto采纳,获得10
20秒前
22秒前
超帅青烟完成签到,获得积分10
22秒前
22秒前
科目三应助KK采纳,获得10
23秒前
Shuaibin_Pei完成签到,获得积分10
26秒前
张今天也要做科研呀完成签到,获得积分10
26秒前
shinysparrow完成签到,获得积分0
26秒前
传奇3应助LJJ采纳,获得10
27秒前
28秒前
29秒前
科研蚂蚁完成签到,获得积分10
30秒前
桃子完成签到 ,获得积分10
30秒前
魁梧的鲂发布了新的文献求助10
33秒前
健忘白应助su采纳,获得10
33秒前
Culto发布了新的文献求助10
34秒前
35秒前
猫猫完成签到,获得积分10
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173