已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis

非酒精性脂肪肝 医学 内科学 肠道微生物群 荟萃分析 脂肪肝 基因组 非酒精性脂肪性肝炎 微生物群 计算生物学 生物信息学 疾病 基因 生物 遗传学
作者
Yijia Song,Sutong Liu,Lihui Zhang,Wenxia Zhao,Yuanmei Qin,Minghao Liu
出处
期刊:Frontiers in Nutrition [Frontiers Media]
卷期号:11
标识
DOI:10.3389/fnut.2024.1470185
摘要

The incidence of NAFLD is increasing. Preclinical evidences indicate that modulation of the gut microbiome could be a promising target in nonalcoholic fatty liver disease. A systematic review and network meta-analysis was conducted to compare the effect of probiotics, synbiotics, prebiotics, fecal microbiota transplant, and antibiotics on the liver-enzyme, metabolic effects and liver-specific in patients with NAFLD. The randomized controlled trails (RCTs), limited to English language were searched from database such as Pubmed, Embase, Web of science and Cochrane Library from inception to November 2024. Review Manager 5.3 was used to to draw a Cochrane bias risk. Inconsistency test and publication-bias were assessed by Stata 14.0. Random effect model was used to assemble direct and indirect evidences. The effects of the intervention were presented as mean differences with 95% confidence interval. A total of 1921 patients from 37 RCTs were eventually included in our study. 23 RCTs evaluated probiotics, 10 RCTs evaluated synbiotics, 4 RCTs evaluated prebiotics, 3 RCTs evaluated FMT and one RCT evaluated antibiotics. Probiotics and synbiotics were associated with a significantly reduction in alanine aminotransferase [ALT, (MD: -5.09; 95%CI: -9.79, -0.39), (MD: -7.38, 95CI%: -11.94, -2.82)] and liver stiffness measurement by elastograph [LSM, (MD: -0.37;95%CI: -0.49, -0.25), (MD: -1.00;95%CI: -1.59, -0.41)]. In addition to, synbiotics was superior to probiotics in reducing LSM. Synbiotics was associated with a significant reduction of Controlled Attenuation Parameter [CAP, (MD: -39.34; 95%CI: -74.73, -3.95)]. Both probiotics and synbiotics were associated with a significant reduction of aspartate transaminase [AST, (MD: -7.81; 95%CI: -15.49, -0.12), (MD: -13.32; 95%CI: -23, -3.64)]. Probiotics and Allogenic FMT was associated with a significant reduction of Homeostatic Model Assessment for Insulin Resistance [HOMA-IR, (MD: -0.7, 95%CI: -1.26, -0.15), (MD: -1.8, 95%CI: -3.53, - 0.07)]. Probiotics was associated with a significant reduction of body mass index [BMI, MD: -1.84, 95%CI: -3.35, -0.33]. The supplement of synbiotics and probiotics maybe a promising way to improve liver-enzyme, LSM, and steatosis in patients with NAFLD. More randomized controlled trials are needed to determine the efficacy of FMT and antibiotics on NAFLD. And the incidence of adverse events of MTTs should be further explored. https://www.crd.york.ac.uk/prospero/, CRD42023450093.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
iNk应助niuma采纳,获得20
1秒前
1秒前
Xangel发布了新的文献求助10
3秒前
4秒前
kannakaco完成签到,获得积分10
4秒前
4秒前
xxxrass完成签到,获得积分20
4秒前
时闲发布了新的文献求助10
4秒前
小橘猫完成签到,获得积分10
5秒前
Rondab应助tonyguo采纳,获得10
6秒前
6秒前
培乐多完成签到,获得积分10
7秒前
斑鸠完成签到,获得积分10
7秒前
顾矜应助俏皮的白柏采纳,获得10
7秒前
花痴的小松鼠完成签到 ,获得积分10
7秒前
张琳琳发布了新的文献求助10
7秒前
CodeCraft应助kannakaco采纳,获得10
8秒前
李健应助momo采纳,获得10
9秒前
迷你的颖发布了新的文献求助10
10秒前
12秒前
万能图书馆应助Shutai采纳,获得10
12秒前
mumu完成签到,获得积分10
14秒前
丘比特应助迷你的颖采纳,获得10
17秒前
18秒前
tonyguo完成签到,获得积分10
18秒前
沉静的时光完成签到 ,获得积分10
19秒前
画清风完成签到,获得积分10
19秒前
山上完成签到,获得积分10
21秒前
zzzllove完成签到 ,获得积分10
23秒前
24秒前
今后应助d董采纳,获得30
25秒前
斯文败类应助nito采纳,获得10
25秒前
Cherry发布了新的文献求助10
26秒前
Chelry发布了新的文献求助10
28秒前
SUE发布了新的文献求助10
29秒前
31秒前
爱学习的孩纸完成签到 ,获得积分10
32秒前
共享精神应助非也非也6采纳,获得10
33秒前
34秒前
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989811
求助须知:如何正确求助?哪些是违规求助? 3531927
关于积分的说明 11255560
捐赠科研通 3270706
什么是DOI,文献DOI怎么找? 1805035
邀请新用户注册赠送积分活动 882181
科研通“疑难数据库(出版商)”最低求助积分说明 809190