光热治疗
光纤
材料科学
纳米技术
生物医学工程
光电子学
医学
计算机科学
电信
作者
Fangzhou Jin,Zhiyuan Xu,Wei Wang,Zhongyuan Cheng,Yang‐Chang Wu,Zesen Li,Enlai Song,Yue Xu,Yong Kang Zhang,Wei Li,You‐Zhen Feng,Donglin Cao,Dongmei Zhang,Minfeng Chen,Xiang‐Ran Cai,Yang Ran,Bai‐Ou Guan
标识
DOI:10.1002/smsc.202400450
摘要
Efficient delivery of photons to visceral organs is critical for the treatment of deep‐seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, an integrated fiber‐optic theranostic (iFOT) probe is developed that merges tumor microenvironment sensing and photothermal therapy by functionalizing the fiber with graphene/gold nanostar hybrid materials and hypoxic‐responsive fluorophores. The iFOT probe can quickly detect the hypoxia of xenograft tumors of mice with high sensitivity. The tumors can be photothermally killed on‐site through the same fiber probe tightly followed by detection, which presents a high cure rate. More importantly, the iFOT is highly adaptable to the conventional medical imaging and endoscopic techniques, which facilitates the imaging‐assisted navigation and manipulation by use of the interventional trocar. The proposed strategy can be used as an effective endoscopic and interventional tool for tackling deep‐situated tumor and may open a revolutionized pathway to bridge separate diagnosis and therapy process in the current stage.
科研通智能强力驱动
Strongly Powered by AbleSci AI