Efficacy and safety of a novel weekly topical metformin-loaded peel-off mask in the treatment of melasma: a split-face, placebo-controlled study

Melasma is a common condition that affects a patient's quality of life. Metformin is a cheap, well-tolerated and relatively safe medication that is widely prescribed for the treatment of diabetes. Topical metformin has shown promising results in treating melasma as well as several other dermatological conditions such as acne and recalcitrant central centrifugal cicatricial alopecia.