Identification of the fruit of Brucea javanica as an anti−liver fibrosis agent working via SMAD2/SMAD3 and JAK1/STAT3 signaling pathways

• The fruit of Brucea javanica as a traditional Chinese medicine has the potential antifibrotic properties. • The mechanism of the fruit of Brucea javanica attenuated liver fibrosis is inhibiting SMAD2/SMAD3 and JAK1/STAT3 signaling pathways. • Cynaroside is one of the active compounds of the fruit of Brucea javanica that could reproduce its antifibrotic effects.