Role of MTHFR, IRF6, PAX7 and TP63 SNPs in susceptibility to non‐syndromic orofacial cleft, a candidate gene study in a Portuguese population

Non-syndromic orofacial cleft (NSOC) is a complex phenotype, involving multiple genetic and environmental factors. Association studies exploring the genetic susceptibility to this prevalent oral malformation show variability of results in different populations. Using a candidate gene approach, we aimed to verify the role of four single-nucleotide polymorphisms (SNPs) in the susceptibility to NSOC in Portuguese patients.