硼
光热治疗
材料科学
谷胱甘肽
中子俘获
细胞内
肿瘤微环境
癌症研究
癌细胞
放射治疗
毒性
旁观者效应
癌症
纳米技术
生物物理学
化学
医学
肿瘤细胞
生物化学
生物
免疫学
有机化学
内科学
酶
作者
Mixue Wang,Haotian Hao,Peirong Bai,Jiayan Wu,Zizhu Zhang,Tong Liu,Yongzhen Yang,Liping Li,Kanyi Pu,Ruiping Zhang
标识
DOI:10.1002/adfm.202407468
摘要
Abstract Boron neutron capture therapy (BNCT) as a binary targeted particle radiotherapy strategy has shown potent anti‐cancer potential. However, biological barriers and restricted blood supply pose challenges in achieving adequate boron concentration within deep‐seated tumor lesions. BNCT with other anti‐cancer therapies, such as X‐ray radiotherapy and photothermal therapy, is devised to address the limitations of BNCT efficiency. However, the potential risk of organ‐accumulating toxicity and treatment complexity of dual exogenous activation hinders its development. To address this problem, newly redox‐responsive boron nano‐chains (RBNC) are reported that combine BNCT and endogenous chemodynamic therapy (CDT)‐enhanced ferroptosis. RBNC specifically activates nanoparticle size conversion (large‐to‐small) in response to GSH/H 2 O 2 in the tumor microenvironment, releasing boron delivery agents boron quantum dots (BQD) and Fe 3+ . RBNC exhibits negligible systemic toxicity while demonstrating high boron accumulation at tumor. Meanwhile, the introduction of Fe 3+ not only produces ·OH through reaction with H 2 O 2 , but also depletes GSH and reduces GPX4 activity in tumors, resulting in amplified intracellular oxidative stress and chemodynamically enhanced ferroptosis. Thus, the work provides a strategy to solve the problem of insufficient boron concentration and poor targeting of boron delivery agents and fill the gaps of BNCT combined with CDT and ferroptosis.
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