胰岛素抵抗
2型糖尿病
淀粉样蛋白(真菌学)
BETA(编程语言)
内科学
医学
内分泌学
糖尿病
胰岛素
计算机科学
病理
程序设计语言
作者
Alessandra Lucia Fluca,B. Pani,Milijana Janjusevic,Donna R. Zwas,Yishak Abraham,Matteo Calligaris,Antonio Paolo Beltrami,Flávia Campos Corgosinho,Maria Marketou,Stefano D’Errico,Gianfranco Sinagra,Aneta Aleksova
出处
期刊:Life Sciences
[Elsevier]
日期:2024-07-01
卷期号:: 122911-122911
被引量:2
标识
DOI:10.1016/j.lfs.2024.122911
摘要
The concept of "type 3 diabetes" has emerged to define alterations in glucose metabolism that predispose individuals to the development of Alzheimer's disease (AD). Novel evidence suggests that changes in the insulin/insulin-like growth factor 1 (IGF-1)/growth hormone (GH) axis, which are characteristic of Diabetes Mellitus, are one of the major factors contributing to excessive amyloid-beta (Aβ) production and neurodegenerative processes in AD. Moreover, molecular findings suggest that insulin resistance and dysregulated IGF-1 signaling promote atherosclerosis via endothelial dysfunction and a pro-inflammatory state. As the pathophysiological role of Aβ1-40 in patients with cardiovascular disease has attracted attention due to its involvement in plaque formation and destabilization, it is of great interest to explore whether a paradigm similar to that in AD exists in the cardiovascular field. Therefore, this review aims to elucidate the intricate interplay between insulin resistance, IGF-1, and Aβ1-40 in the cardiovascular system and assess the applicability of the type 3 diabetes concept. Understanding these relationships may offer novel therapeutic targets and diagnostic strategies to mitigate cardiovascular risk in patients with insulin resistance and dysregulated IGF-1 signaling.
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