清脆的
基因组编辑
Cas9
移码突变
计算生物学
基因组
计算机科学
遗传学
基因
生物
医学
生物信息学
突变
作者
Araceli Gutiérrez-Rodríguez,Carlos Cruz-Fuentes,Alma Delia Genis‐Mendoza,Humberto Nicolini
标识
DOI:10.47626/1516-4446-2022-2913
摘要
Currently, genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), are predominantly used to model genetic diseases. This genome editing system can correct point or frameshift mutations in risk genes. Here, we analyze and discuss the advantages of genome editing, its current applications, and the feasibility of the CRISPR/Cas9 system in research on psychiatric disorders. These disorders produce cognitive and behavioral alterations and their etiology is associated with polygenetic and environmental factors. CRISPR/Cas9 may reveal the biological mechanisms of psychiatric disorders at a basic research level, translating a suitable clinical approach for use in the diagnosis and treatment of psychiatric disorders. Genetic diagnosis and treatment for these disorders have not yet been fully established in psychiatry due to the limited understanding of their heterogeneity and polygenicity. We discuss the challenges and ethical issues in using CRISPR/Cas9 as a tool for diagnosis or gene therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI