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Association of exposure to per- and polyfluoroalkyl substances with hemoglobin and hematocrit during pregnancy

血红蛋白 怀孕 红细胞压积 医学 脐带血 生理学 队列 内科学 产科 生物 遗传学
作者
Fengzhen Cui,Hongxiu Liu,Yuanyuan Li,Tongzhang Zheng,Shunqing Xu,Wei Xia,Xia Sheng
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier BV]
卷期号:248: 114319-114319 被引量:7
标识
DOI:10.1016/j.ecoenv.2022.114319
摘要

Per- and polyfluoroalkyl substances (PFASs) are common environmental contaminants and are widely detected in humans. Previous studies have linked PFASs exposure to adverse birth outcomes. However, the association between maternal exposure to PFASs and hemoglobin (Hb) and hematocrit (HCT) remains unclear. We aimed to explore the relationship between PFASs exposure with Hb and HCT during pregnancy. The present birth cohort study included 1044 pregnant women from Wuhan, China. Maternal HCT and Hb were measured in the first, second and third trimesters, and 13 PFASs were detected in the cord sera. Mixed linear models and general linear regression were applied to analyze the association between each single PFASs and Hb and HCT. Weighted quantile sum (WQS) regressions were used to investigate the association between PFASs mixture and Hb and HCT during pregnancy. In single-PFAS models, 10 PFASs were positively associated with HCT and Hb across pregnancy (a 10-fold increase in PFASs was associated with 1.47–3.54 % change in HCT and 1.46–3.20 % change in Hb (All P-FDR < 0.05). In addition, Hb and HCT were more positively related to PFASs in the second and third trimesters rather than the first trimester. The association between PFASs exposure and maternal HCT and Hb was not significant in the iron supplementation group, whereas significant in the non-iron supplementation group. A significant interaction between iron supplementation and non-iron supplementation was also detected. WQS regressions showed that perfluorononanoic acid (PFNA) and perfluorohexane sulfonate (PFHxS) contributed most to the association between PFASs and HCT and Hb in the second and third trimesters, respectively. Maternal PFASs exposure was positive with serum Hb and HCT. Moreover, maternal iron supplementation may play a modifying effect in influencing the relationship between PFASs and HCT and Hb.
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