伏隔核
被盖腹侧区
神经科学
加巴能
光遗传学
多巴胺
扁桃形结构
基底外侧杏仁核
脑刺激奖励
奖励制度
外侧下丘脑
心理学
下丘脑
抑制性突触后电位
多巴胺能
作者
Kai Zhou,Hua Xu,Lu Shen,Shaolei Jiang,Guanyu Hou,Xiaofei Deng,Miao He,Ying‐Jie Zhu
标识
DOI:10.1038/s41467-022-33843-3
摘要
The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elusive. Here, using the recently developed AAV1-mediated anterograde transsynaptic tagging technique in mice, we show that NAc neurons receiving basolateral amygdala inputs (NAcBLA) promote positive reinforcement via disinhibiting dopamine neurons in the ventral tegmental area (VTA). In contrast, NAc neurons receiving paraventricular thalamic inputs (NAcPVT) innervate GABAergic neurons in the lateral hypothalamus (LH) and mediate aversion. Silencing the synaptic output of NAcBLA neurons impairs reward seeking behavior, while silencing of NAcPVT or NAcPVT→LH pathway abolishes aversive symptoms of opiate withdrawal. Our results elucidate the afferent-specific circuit architecture of the NAc in controlling reward and aversion.
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