异黄酮素
抗菌活性
抗菌剂
多酚
化学
细菌
消炎药
抗氧化剂
传统医学
微生物学
生物
生物化学
药理学
医学
遗传学
作者
Hongbo Dong,Yufei Che,Xingtong Zhu,Yi Zhong,Jiafu Lin,Jian Wang,Weihong Du,Tao Song
出处
期刊:Molecules
[MDPI AG]
日期:2024-05-30
卷期号:29 (11): 2574-2574
被引量:2
标识
DOI:10.3390/molecules29112574
摘要
Isoflavones are a class of natural products that exhibit a wide range of interesting biological properties, including antioxidant, hepatoprotective, antimicrobial, and anti-inflammatory activities. Scandenone (1), osajin (2), and 6,8-diprenylgenistein (3) are natural prenylated isoflavones that share the same polyphenol framework. In this research, the key intermediate 15 was used for the synthesis of the natural isoflavones 1–3, establishing a stereoselective synthetic method for both linear and angular pyran isoflavones. The antibacterial activities of 1–3 were also evaluated, and all of them displayed good antibacterial activity against Gram-positive bacteria. Among them, 2 was the most potent one against MRSA, with a MIC value of 2 μg/mL, and the SEM assay indicated that the bacterial cell membranes of both MRSA and E. faecalis could be disrupted by 2. These findings suggest that this type of isoflavone could serve as a lead for the development of novel antibacterial agents for the treatment of Gram-positive bacterial infections.
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