涂层
纳米晶
纳米颗粒
光热治疗
材料科学
离子
聚合物
放松(心理学)
纤维素
吸附
化学工程
纳米技术
化学
复合材料
物理化学
有机化学
心理学
社会心理学
工程类
作者
Yang Shen,Xin Li,Haitao Huang,Yu Lan,Lin Gan,Jin Huang
标识
DOI:10.1016/j.carbpol.2022.120061
摘要
Grafting Mn ions on 1D particles can produce high-performance MRI agents. However, the motion of Mn ions may cause Mn aggregation and then attenuate imaging contrast. Here, we proposed an MRI-promotion strategy based on embedding Mn2+ into crosslinked polydopamine (PDA) coating on rod-like cellulose nanocrystals. The results indicate that the slow relaxation of PDA molecular chains restricts the motion of embedded Mn2+. When the embedded Mn2+ content raises up to 2.25 wt%, the particles display a longitudinal relaxivity of 38.08 mM-1·s-1. Such a relaxivity is over 6.6 times of the sample with adsorbed 0.65 wt% Mn2+. The aspect ratio of nanoparticles even increases from 14.2 to 20.7 as embedding Mn2+ concentration increases. Then, the photothermal conversion efficiency of nanoparticles increases from 17.7 % to 44.4 %. This high photothermal conversion efficiency contributes this kind of MRI agent with embedded Mn2+ to the application potential of integrating tumor diagnosis and treatment.
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