巴贝虫
生物
巴贝虫病
抗寄生虫的
牛巴贝虫
泰勒虫
有机体
抗寄生虫药
模式生物
疟疾
计算生物学
病毒学
微生物学
免疫学
寄生虫寄主
遗传学
药理学
医学
基因
万维网
病理
计算机科学
作者
Tiffany Fang,Choukri Ben Mamoun
标识
DOI:10.1093/infdis/jiae191
摘要
Abstract Pathogens such as Plasmodium, Babesia, and Theileria invade and multiply within host red blood cells, leading to the pathological consequences of malaria, babesiosis, and theileriosis. Establishing continuous in vitro culture systems and suitable animal models is crucial for studying these pathogens. This review spotlights the Babesia duncani in culture-in mouse (ICIM) model as a promising resource for advancing research on the biology, pathogenicity, and virulence of intraerythrocytic parasites. The model offers practical benefits, encompassing well-defined culture conditions, ease of manipulation, and a well-annotated genome. Moreover, B. duncani serves as a surrogate system for drug discovery, facilitating the evaluation of new antiparasitic drugs in vitro and in animals, elucidating their modes of action, and uncovering potential resistance mechanisms. The B. duncani ICIM model thus emerges as a multifaceted tool with profound implications, promising advancements in our understanding of parasitic biology and shaping the development of future therapies.
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