Molecularly imprinted polymers for sensing/depleting human serum albumin (HSA): A critical review of recent advances and current challenges

Human serum albumin (HSA) is an essential biomacromolecule in the blood circulatory system because it carries numerous molecules, including fatty acids (FAs), bilirubin, metal ions, hormones, and different pharmaceuticals, and plays a significant role in regulating blood osmotic pressure. Fluctuations in HSA levels in human biofluids, particularly urine and serum, are associated with several disorders, such as elevated blood pressure, diabetes mellitus (DM), liver dysfunction, and a wide range of renal diseases. Thus, the ability to quickly and accurately measure HSA levels is important for the rapid identification of these disorders in human populations. Molecularly imprinted polymers (MIPs), well known as artificial antibodies (Abs), have been extensively used for the quantitative detection of small molecules and macromolecules, especially HSA, in recent decades. This review highlights major challenges and recent developments in the application of MIPs to detect HSA in artificial and real samples. The fabrication and application of various MIPs for the depletion of HSA are also discussed, as well as different MIP preparation approaches and strategies for overcoming obstacles that hinder the development of MIPs with high efficiency and recognition capability for HSA determination/depletion.