医学
心肌梗塞
重症监护医学
危险分层
心力衰竭
病理生理学
疾病
病态的
心室重构
心脏病学
内科学
作者
Stefan Frantz,Moritz Hundertmark,Jeanette Schulz‐Menger,Frank M. Bengel,Johann Bauersachs
标识
DOI:10.1093/eurheartj/ehac223
摘要
Abstract Most patients survive acute myocardial infarction (MI). Yet this encouraging development has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend to have more comorbidities worsening economic strain on healthcare systems and impeding effective medical management. The heart’s pathological changes in structure and/or function, termed myocardial remodelling, significantly impact on patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, female sex, and others distinctly shape disease progression on the ‘road to HF’. Despite the availability of HF drugs that interact with general pathways involved in myocardial remodelling, targeted drugs remain absent, and patient risk stratification is poor. Hence, in this review, we highlight the pathophysiological basis, current diagnostic methods and available treatments for cardiac remodelling following MI. We further aim to provide a roadmap for developing improved risk stratification and novel medical and interventional therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI