2019年冠状病毒病(COVID-19)
Spike(软件开发)
2019-20冠状病毒爆发
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
信使核糖核酸
病毒学
生物
医学
遗传学
病理
爆发
基因
计算机科学
传染病(医学专业)
疾病
软件工程
作者
Ioannis P. Trougakos,Evangelos Terpos,Harry Alexopoulos,Marianna Politou,Dimitrios Paraskevis,Andreas Scorilas,Efstathios Kastritis,Evangelos Andreakos,Meletios Α. Dimopoulos
标识
DOI:10.1016/j.molmed.2022.04.007
摘要
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19) pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is undoubtedly saving thousands of lives. However, adverse effects (AEs) following vaccination have been noted which may relate to a proinflammatory action of the lipid nanoparticles used or the delivered mRNA (i.e., the vaccine formulation), as well as to the unique nature, expression pattern, binding profile, and proinflammatory effects of the produced antigens – spike (S) protein and/or its subunits/peptide fragments – in human tissues or organs. Current knowledge on this topic originates mostly from cell-based assays or from model organisms; further research on the cellular/molecular basis of the mRNA vaccine-induced AEs will therefore promise safety, maintain trust, and direct health policies.
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