生物
胶质瘤
吞噬作用
启动(农业)
巨噬细胞
获得性免疫系统
先天免疫系统
抗原呈递
免疫系统
下调和上调
癌症研究
细胞
细胞生物学
T细胞
免疫学
体外
生物化学
发芽
基因
植物
作者
Jiajie Tu,Yingying Fang,Dafei Han,Xiaosheng Tan,Zhen Xu,Hua Jiang,Xinming Wang,Wenming Hong,Wei Wei
出处
期刊:Oncogene
[Springer Nature]
日期:2022-03-12
卷期号:41 (17): 2444-2457
被引量:6
标识
DOI:10.1038/s41388-022-02236-7
摘要
Macrophage-mediated tumor cell phagocytosis and subsequent neoantigen presentation are critical for generating anti-tumor immunity. This study aimed to uncover the potential clinical value and molecular mechanisms of miRNA-22 (miR-22) in tumor cell phagocytosis via macrophages and more efficient T cell priming. We found that miR-22 expression was markedly downregulated in primary macrophages from glioma tissue samples compared to adjacent tissues. miR-22-overexpressing macrophages inhibited glioma cell proliferation and migration, respectively. miR-22 upregulation stimulated the phagocytic ability of macrophages, enhanced tumor cell phagocytosis, antigen presentation, and efficient T cell priming. Additionally, our data revealed that miR-22-overexpressing macrophages inhibited glioma formation in vivo, HDAC6 was a target, and NF-κB signaling was a pathway closely associated with miR-22 in tumor-associated macrophages (TAMs) of glioma. Our findings revealed the essential roles of miR-22 in tumor cell phagocytosis by macrophages and more efficient T cell priming, facilitating further research on phagocytic regulation to enhance the response to tumor immunotherapy.
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