卵巢孔
生物
卵子发生
卵巢
家蚕
卵母细胞
卵黄发生
细胞生物学
性腺
遗传学
内分泌学
基因
胚胎
作者
Miyu Tanaka,Tsuguru Fujii,Hiroaki Mon,Jae Man Lee,Kohei Kakino,Hisayoshi Fukumori,Takeru Ebihara,Takumi Nagasato,Masato Hino,Yoshino Tonooka,Takato Moriyama,Ryosuke Fujita,Yutaka Banno,Takahiro Kusakabe
标识
DOI:10.1016/j.ibmb.2022.103737
摘要
The ovary is an important organ in reproduction. In insects, especially lepidopteran insects, the oocytes and reproductive organs develop rapidly during the pupal stage. Despite their drastic morphological changes, the molecular mechanisms of ovary development are not fully understood. In this study, it is found that forkhead box transcription factor L2, member 1 (FoxL21), which is known to be involved in ovarian differentiation and maintenance in vertebrates, is required for the development of the ovary in the silkworm, Bombyx mori. FoxL21 was expressed in the ovary and ovariole during the larval and pupal stage, respectively. In silkworms in which FoxL21 was knocked out by genome editing, multiple ovarian dysfunctions, such as, abnormal egg formation, thinning of the ovariole sheaths, and defective connection of the oviductus geminus with the ovariole were observed. Finally, ovarian transplantation experiments using the knockout silkworms revealed that FoxL21 functions in the ovariole, but not in the oviductus geminus.
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