环状RNA
癌变
调节器
炎症
抑制器
生物
癌症研究
神经科学
病态的
生物信息学
核糖核酸
计算生物学
医学
免疫学
癌症
病理
遗传学
基因
作者
Kaixin Su,Yanjiang Qiao,Xianzhong Dai,Ousheng Liu
出处
期刊:Biomolecules
[MDPI AG]
日期:2022-02-24
卷期号:12 (3): 359-359
被引量:10
摘要
In the last decade, numerous circRNAs were discovered by virtue of the RNA-Seq technique. With the deepening of experimental research, circRNAs have brought to light the key biological functions and progression of human diseases. CircRNA ITCH has been demonstrated to be a tumor suppressor in numerous cancers, and recently it was found to play an important role in bone diseases, diabetes mellitus, and cardiovascular diseases. However, the functions of circ-ITCH have not been completely understood. In this review, we comprehensively provide a conceptual framework to elucidate circ-ITCH biological functions of cell proliferation, apoptosis and differentiation, and the pathological mechanisms of inflammation, drug resistance/toxicity, and tumorigenesis. Finally, we summarize its clinical applications in various diseases. This research aimed at clarifying the role of circ-ITCH, which could be a promising therapeutic target.
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