GPX4
神经退行性变
硒代半胱氨酸
生物
程序性细胞死亡
细胞生物学
疾病
遗传学
氧化应激
医学
生物化学
细胞凋亡
半胱氨酸
过氧化氢酶
谷胱甘肽过氧化物酶
酶
病理
作者
Thamara Nishida Xavier da Silva,José Pedro Friedmann Angeli,Irina Ingold
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2022-06-27
卷期号:50 (3): 1205-1213
被引量:23
摘要
GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide newcomers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries.
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