Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

In light of our mission to find novel therapeutic targets to stimulate atherosclerotic lesion regression, we have reviewed with great interest the data presented by Zhang et al. in Atherosclerosis which suggest that global inhibition of PLTP activity facilitates the disappearance of macrophages from regressing atherosclerotic lesions [ [1] Zhang K. Zheng J. Chen Y. Dong J. Li Z. Chiang Y.P. He M. Huang Q. Tang H. Jiang X.C. Inducible phospholipid transfer protein deficiency ameliorates atherosclerosis. Atherosclerosis. 2021; 324: 9-17 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar ]. PLTP deficiency-mediated atherosclerosis regression could be related to sphinogosine-1-phosphate reductionAtherosclerosisVol. 356PreviewWe appreciate the positive comment, from Drs. Menno Hoekstra, Ezra J. van der Wel, and Miranda Van Eck, on our recent work of PLTP deficiency-mediated atherosclerosis regression [1]. We agree that the lesion regression effect observed by us can also be attributed to the effect of PLTP deficiency specifically in macrophages, although the mechanism remains unclear. Full-Text PDF