生物相容性
伤口愈合
再生(生物学)
膜
伤口敷料
静电纺丝
生物医学工程
材料科学
糖尿病溃疡
化学
外科
医学
糖尿病
细胞生物学
复合材料
生物化学
有机化学
生物
糖尿病足
内分泌学
聚合物
作者
Ma Yu,Pengfei Tang,Youhong Tang,Cheng Wei,Zhenming Wang,Hongping Zhang
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-05-20
卷期号:5 (6): 2894-2901
被引量:10
标识
DOI:10.1021/acsabm.2c00255
摘要
Diabetic wound tissue repair and regeneration is a multi-step process that includes cell proliferation and migration, gas and moisture management, and inflammatory responses. However, current wound dressing designs lack consideration of the wound microenvironment of diabetic patients, making diabetic wound tissue repair a challenge. Here, we report a wound dressing (SSD-PG-PVA/KGM) with a porous structure and anti-oxidant properties for promoting diabetic wound tissue repair. First, the porous structure created by electrospinning technology encourages cell proliferation and migration in the wound while also providing breathability and moisture retention. Second, adding natural polyphenols (PG) and saikosaponins (SSDs) to the wound reduced reactive oxygen species levels and oxide stress. In vitro cell experiments showed that SSD-PG-PVA/KGM had good biocompatibility. Due to the biocompatibility, anti-oxidation ability, breathability, and moisturizing, SSD-PG-PVA/KGM could effectively promote the repair of diabetic wound tissue (the wound closure rate was 95.6% at 14 days).
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