Sex is a major effect modifier between body composition and mortality in patients with cirrhosis assessed for liver transplantation

医学 肝移植 肌萎缩 内科学 队列 肝硬化 移植 体质指数 肝病 脂肪组织 胃肠病学 队列研究
作者
Amine Benmassaoud,Davide Roccarina,Francesco Marcello Aricò,Marta Cilla,Rossella Donghia,Gioacchino Leandro,Laura Iogna Prat,Mohamed Zuhair,Matthew North,Orla Kearney,John Ryan,Emmanuel Tsochatzis
出处
期刊:Liver International [Wiley]
卷期号:43 (1): 160-169 被引量:11
标识
DOI:10.1111/liv.15293
摘要

Body composition predicts mortality in patients with cirrhosis. The impact of sex on this association is unknown. We investigated the impact of sex on this association in patients with cirrhosis assessed for liver transplantation.This single-centre retrospective cohort study included adults assessed for liver transplantation. Nutritional status was assessed using the Royal Free Hospital-Global Assessment (RFH-GA). Body composition at the third lumbar vertebrae was determined. SarcopeniaSMI was defined as Skeletal Muscle Index <50 cm2 /m2 in males and <39 cm2 /m2 in females. SarcopeniaPMI was defined as the sex-specific 25th percentile of the Psoas Muscle Index. Patients were assessed for the occurrence of liver transplantation and death. Analyses were stratified by sex.The cohort comprised 628 patients, including 199 females and 429 males. Both groups were similar in terms of baseline liver disease severity by Model for End-stage Liver Disease (MELD) (p = .98) and nutritional status (p = .24). SarcopeniaSMI was present in 41% of males compared to 27% of females (p < .001). In the male cohort, when adjusted for age and MELD, sarcopeniaPMI (aHR 1.74, 95% CI 1.08-2.80) and RFH-GA (aHR 1.40, 95% CI 1.03-1.90) remained independent predictors of mortality. Adipose tissue had no impact on outcomes in males. In female patients, adipose tissue (TATI or VATI depending on the multivariable model) was independently associated with mortality, whereas sarcopenia and malnutrition were not.This study demonstrates that male patients were susceptible to low muscle mass, whereas female patients were not. Future research in this patient population should minimize sex-related bias and present data for both groups separately.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
bkagyin应助Islet采纳,获得10
刚刚
刚刚
11完成签到,获得积分20
1秒前
小飞发布了新的文献求助10
1秒前
xiaolianwheat发布了新的文献求助10
1秒前
2秒前
英姑应助ZX801采纳,获得10
2秒前
2秒前
不要引力发布了新的文献求助10
2秒前
3秒前
3秒前
不再选择完成签到,获得积分10
3秒前
科目三应助钢笔采纳,获得10
3秒前
斯文败类应助轻狂采纳,获得10
4秒前
4秒前
自信又菡发布了新的文献求助20
4秒前
大个应助简单如容采纳,获得10
4秒前
5秒前
5秒前
5秒前
赘婿应助李一鹏采纳,获得30
5秒前
耿昭发布了新的文献求助10
5秒前
ccccccwq完成签到,获得积分10
5秒前
6秒前
Hygge发布了新的文献求助10
7秒前
赘婿应助xiaolianwheat采纳,获得10
7秒前
岳岳岳发布了新的文献求助10
7秒前
枸橼酸发布了新的文献求助10
8秒前
8秒前
9秒前
车紊完成签到,获得积分10
9秒前
pursue发布了新的文献求助10
9秒前
Inevitable发布了新的文献求助10
9秒前
9秒前
9秒前
mensa发布了新的文献求助10
10秒前
宋佳佳发布了新的文献求助10
10秒前
flyingsoul发布了新的文献求助10
10秒前
小小人儿完成签到,获得积分10
11秒前
11秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546888
求助须知:如何正确求助?哪些是违规求助? 3123917
关于积分的说明 9357332
捐赠科研通 2822504
什么是DOI,文献DOI怎么找? 1551513
邀请新用户注册赠送积分活动 723546
科研通“疑难数据库(出版商)”最低求助积分说明 713791