炔烃
克莱森重排
化学
分子内力
布朗斯特德-洛瑞酸碱理论
重排
催化作用
原子经济
分子间力
组合化学
有机化学
分子
作者
Long Li,Long‐Wu Ye,Yao-Hong Yan
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2022-01-13
卷期号:33 (18): 1813-1818
被引量:5
标识
DOI:10.1055/s-0040-1719866
摘要
Abstract Over the past two decades, catalytic alkyne alkoxylation-initiated Claisen rearrangement has proven to be a practical and powerful strategy for the rapid assembly of a diverse range of structurally complex molecules. The rapid development of Claisen rearrangements triggered by transition-metal-catalyzed alkyne alkoxylation has shown great potential in the formation of carbon–carbon bonds in an atom-economic and mild way. However, metal-free alkyne alkoxylation-triggered Claisen rearrangement has seldom been exploited. Recently, Brønsted acids such as HNTf2 and HOTf have been shown to be powerful activators that promote catalytic alkyne alkoxylation/Claisen rearrangement, leading to the concise and flexible synthesis of valuable compounds with high efficiency and atom economy. Recent advances on the Brønsted acid catalyzed alkyne alkoxylation/Claisen rearrangement are introduced in this Account, in which both intramolecular and intermolecular tandem reactions are discussed.
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