Copper-catalyzed C-H/N-H annulation of enaminones and alkynyl esters for densely substituted pyrrole synthesis

Herein, the copper-catalyzed annulation of enaminones with alkynyl esters for the facile synthesis of different pyrroles with 2,3,4,5-tetrasubstituted structure has been developed. With Cu(OAc)2 as the only catalyst, the tunable...