4‐Methyl‐1‐(2‐(Phenylsulfonyl)Ethyl)‐2,6,7‐Trioxabicyclo[2.2.2]Octane

Abstract This article reports the synthesis of 4‐methyl‐1‐(2‐(phenylsulfonyl)ethyl)‐2,6,7‐trioxabicyclo[2.2.2]octane. Ghosez reagent functions as a useful d 3 ‐synthon or homoenolate equivalent as well as a masked electrophilic carbonyl in the acid oxidation state. The reagent has found special use with enantiomerically pure epoxides and aziridines to form enantiomerically pure lactones and lactams, respectively. This reagent is useful in many natural product syntheses.