微流控
电子线路
小型化
流体学
接口
集成电路
软光刻
数码产品
执行机构
纳米技术
电子工程
电气工程
工程类
材料科学
计算机硬件
计算机科学
制作
医学
病理
替代医学
作者
Saurabh Vyawahare,Suresh Sitaula,Sujitha Martin,Dvin Adalian,Axel Scherer
出处
期刊:Lab on a Chip
[Royal Society of Chemistry]
日期:2008-01-01
卷期号:8 (9): 1530-1530
被引量:74
摘要
Recently, sophisticated fluidic circuits with hundreds of independent valves have been built by using multi-layer soft-lithography to mold elastomers. However, this shrinking of microfluidic circuits has not been matched by a corresponding miniaturization of the actuation and interfacing elements that control the circuits; while the fluidic circuits are small (∼10–100 micron wide channels), the Medusa's head-like interface, consisting of external pneumatic solenoids and tubing or mechanical pins to control each independent valve, is larger by one to four orders of magnitude (∼ mm to cm). Consequently, the dream of using large scale integration in microfluidics for portable, high throughput applications has been stymied. By combining multi-layer soft-lithography with shape memory alloys (SMA), we demonstrate electronically activated microfluidic components such as valves, pumps, latches and multiplexers, that are assembled on printed circuit boards (PCBs). Thus, high density, electronically controlled microfluidic chips can be integrated alongside standard opto-electronic components on a PCB. Furthermore, we introduce the idea of microfluidic states, which are combinations of valve states, and analogous to instruction sets of integrated circuit (IC) microprocessors. Microfluidic states may be represented in hardware or software, and we propose a control architecture that results in logarithmic reduction of external control lines. These developments bring us closer to building microfluidic circuits that resemble electronic ICs both physically, as well as in their abstract model.
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