细胞生物学
神经细胞粘附分子
化学
细胞粘附
整合素
免疫球蛋白结构域
克隆(编程)
作者
Peter J. Newman,Michael C. Berndt,Jack Gorski,Gilbert White,Suzanne Lyman,Cathy Paddock,William A. Müller
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1990-03-09
卷期号:247 (4947): 1219-1222
被引量:900
标识
DOI:10.1126/science.1690453
摘要
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.
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